[The treatment of relapsing polychondritis using sulfones. One case (author's transl)].

Abstract

A case of relapsing polychondritis was successfully treated with a daily dose of 120 mg of diaminodiphenylsulfone. Clinical signs (fever, fatigue, conjunctivitis, chondritis and hoarseness of the voice) rapidly regressed and remain so 8 months later, despite a decrease in the dose. Biological parameters returned to normal (sedimentation rate, plasma perchlorosoluble seromucoids, urinary acid mucopolysaccharides), and histological and ultrastructural lesions of the auricular cartilage disappeared. The pathogenic role of a herpes infection at the beginning of the disease is discussed.

• Authors: P Deschamps, D Leroy, J C Mandard, Y Benard
• Journal: La Nouvelle presse medicale (Nouv Presse Med) Vol. 7 Issue 29 Pg. 2549-52 (Sep 09 1978) ISSN: 0301-1518 [Print] France
• Vernacular Title: Traitement de la polychondrite chronique atrophiante par les sulfones. Une observation.
• PMID: 704315 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Dapsone

Topics

• Aged
• Cartilage (ultrastructure)
• Dapsone (therapeutic use)
• Ear, External (pathology)
• Female
• Follow-Up Studies
• Humans
• Polychondritis, Relapsing (drug therapy, pathology)