Cimetidine in the management of symptomatic patients with duodenitis: a double-blind controlled trial.

Abstract

Twenty-one adult outpatients with dyspepsia and endoscopically proven duodenitis without chronic ulceration completed a double-blind trial of either cimetidine (1 g/day) or placebo. Treatment with cimetidine for 6 weeks resulted in a significant improvement in symptoms and in the endoscopic appearance of the duodenitis when compared to treatment with placebo. The symptomatic and endoscopic improvement, however, was not associated with any significant change in the histological grading of the duodenitis.

• Authors: M Mackinnon, R L Willing, R Whitehead
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 27 Issue 3 Pg. 217-9 (Mar 1982) ISSN: 0163-2116 [Print] United States
• PMID: 7042248 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Guanidines
• Placebos
• Cimetidine

Topics

• Cimetidine (therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Duodenitis (drug therapy)
• Duodenoscopy
• Duodenum (anatomy & histology)
• Guanidines (therapeutic use)
• Humans
• Middle Aged
• Placebos