Calcium-oxalate-crystal-induced bone disease.

Abstract

A 13-year-old boy with primary hyperoxaluria and a successful renal allograft developed symptomatic bone disease, hypercalcemia, and hypercalciuria. Transiliac bone biopsy revealed calcium oxalate crystals in the marrow within mononuclear phagocytes and multinucleated giant cells. Deep resorption bays were seen adjacent to these crystal-cell aggregates. Serum 1,25-(OH)2-vitamin D (calcitriol) and iPTH concentrations were low or normal. We suggest that hypercalcemia results from macrophage-mediated bone resorption initiated by Ca oxalate crystal deposition.

• Authors: N D Adams, G F Carrera, R P Johnson, R Latorraca, J Lemann Jr
• Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation (Am J Kidney Dis) Vol. 1 Issue 5 Pg. 294-9 (Mar 1982) ISSN: 0272-6386 [Print] United States
• PMID: 7041638 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Oxalates
• Calcium Oxalate
• Oxalic Acid

Topics

• Adolescent
• Bone Diseases (etiology, pathology)
• Bone Resorption
• Calcium Oxalate (metabolism)
• Humans
• Hypercalcemia (etiology)
• Kidney Transplantation
• Male
• Oxalates (urine)
• Oxalic Acid