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Treatment of ichthyosis with isotretinoin.

Abstract
A multicenter study of the effectiveness of 13-cis-retinoic acid (isotretinoin) in lamellar ichthyosis and epidermolytic hyperkeratosis has been conducted. A dose of the drug which produced maximum clearing with minimum side effects was chosen; this varied among different patients, the mean dose being about 2 mg/kg/day. Almost all of the patients in both groups were clearly improved, as evaluated both by the physicians and the patients. The degree of improvement seemed higher in the group of patients with lamellar ichthyosis.
AuthorsH P Baden, M M Buxman, G D Weinstein, F W Yoder
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 6 Issue 4 Pt 2 Suppl Pg. 716-20 (Apr 1982) ISSN: 0190-9622 [Print] United States
PMID7040514 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Tretinoin
  • Isotretinoin
Topics
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Female
  • Humans
  • Ichthyosis (diagnosis, drug therapy)
  • Infant
  • Isomerism
  • Isotretinoin
  • Male
  • Middle Aged
  • Skin Diseases, Vesiculobullous (drug therapy)
  • Tretinoin (administration & dosage)

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