Suppression of natural tumor resistance by tumor promoters.

Abstract

The findings of the present and other studies (4,7) show that TPA and other tumor-promoting esters suppress various in vitro manifestations of natural cell-mediated tumor resistance: (a) prevention of enhancement of macrophage cytocidal activity; (b) suppression of cytocidal capacity by activated macrophages; and (c) suppression of cytolytic activity of NK cells. Moreover, they abrogate host tumor resistance in vivo. These suppressive effects of tumor promoters on natural antitumor effector systems may constitute a fundamental mechanism in carcinogenesis.

• Authors: R Keller, R Keist, P Köppel, E Hecker
• Journal: Carcinogenesis; a comprehensive survey (Carcinog Compr Surv) Vol. 7 Pg. 643-5 ( 1982) ISSN: 0147-4006 [Print] United States
• PMID: 7039836 (Publication Type: Journal Article)

Chemical References

• Lymphokines
• Macrophage-Activating Factors
• Phorbols
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Cell Line
• Cytotoxicity, Immunologic (drug effects)
• Lymphokines (pharmacology)
• Macrophage Activation
• Macrophage-Activating Factors
• Macrophages (immunology)
• Neoplasms, Experimental (immunology)
• Phorbols (pharmacology)
• Rats
• Tetradecanoylphorbol Acetate (pharmacology)