Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice.

Abstract

Xenografts derived from the neoplastic tissues of children with rhabdomyosarcoma have been used in immune-deprived mice to examine the efficacy of agents known to be active against this disease, and in others that received either limited or no clinical evaluation. Two models were derived; xenografts were established from tumors obtained from either (a) untreated patients or (b) from patients who had become refractory to conventional therapy. Model a identified as being effective each of these clinically used agents: vincristine, dactinomycin, cyclophosphamide, and doxorubicin; mitomycin C and 5-(3,3-dimethyl-1-triazeno)-2-methylimidazole-4-carboxamide also showed activity, as did busulfan in one tumor line. Tumors derived from refractory patients were significantly less responsive to all agents examined.

• Authors: J A Houghton, P J Houghton, A A Green
• Journal: Cancer research (Cancer Res) Vol. 42 Issue 2 Pg. 535-9 (Feb 1982) ISSN: 0008-5472 [Print] United States
• PMID: 7034923 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Bone Marrow Transplantation
• Cell Line
• Child
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Drug Resistance
• Female
• Humans
• Mice
• Neoplasm Transplantation
• Rhabdomyosarcoma (drug therapy, pathology)
• Sarcoma, Experimental (drug therapy)
• Thymectomy
• Time Factors
• Transplantation, Heterologous
• Whole-Body Irradiation