Evidence for polymorphism of alloantigenic transplantation products of the histocompatibility locus (H-4) in linkage group I of Rattus norvegicus.

Abstract

An alloantigenic transplantation system linked to the gene for albinism in linkage group I of Rattus norvegicus has been identified in the congenic pair LEW--LEW.C-4A and designated H-4. Alloantigenic transplantation products of the H-4 system are relatively "weak" because the majority of skin grafts exchanged between animals of the congenic pair (LEW--LEW.C-4A) survive permanently without previous sensitization of the recipients. Presensitization of the congenic recipients with lymphoid cells results in a marked increase in the incidence and acceleration of graft rejection. The testing of F1 hybrids of the eight inbred rat strains with strains LEW and LEW.C-4A by skin or tumour transplantation shows that alleles other than H-4a or H-41 are present in three strains, thereby demonstrating polymorphism of the H-4 system with the existence of minimally three alleles.

• Authors: M Krsiaková, V Kren, A Jirásek
• Journal: Folia biologica (Folia Biol (Praha)) Vol. 27 Issue 4 Pg. 225-32 ( 1981) ISSN: 0015-5500 [Print] Czech Republic
• PMID: 7023998 (Publication Type: Journal Article)

Chemical References

• Histocompatibility Antigens

Topics

• Alleles
• Animals
• Female
• Genetic Linkage
• Graft Rejection
• Histocompatibility Antigens (immunology)
• Immunization
• Lymphocytes (immunology)
• Male
• Neoplasm Transplantation
• Neoplasms, Experimental (immunology)
• Polymorphism, Genetic
• Rats
• Rats, Inbred Lew (immunology)
• Rats, Inbred Strains (immunology)
• Skin Transplantation
• Transplantation Immunology