[Preliminary results on the effects of pretreatment with thymic extract on experimental endotoxin hepatitis in the mouse].

Abstract

The Authors wish to examine the protective effects which a period of pre-treatment with thymostimulin, would have on endotoxin hepatitis, induced in thymectomized and non-thymectomized animals. The test showed that the histological picture and the degree of endotoxinemia, measured with the Lymulus test, benefited from treatment with a thymic extract. This therapy was effect (and was statistically significant) in obtaining an immunorestoring effect (in the thymectomized mouse) and in inducing an immunostimulating effect (in the normal mouse).

• Authors: S Corridori, D Scevola, R Averna
• Journal: Bollettino dell'Istituto sieroterapico milanese (Boll Ist Sieroter Milan) Vol. 60 Issue 1 Pg. 61-8 ( 1981) ISSN: 0021-2547 [Print] Italy
• Vernacular Title: Risultati preliminari sugli effetti di un pretrattamento con estratto timico nell'epatite sperimentale da endotossina nel topo.
• PMID: 7023499 (Publication Type: Journal Article)

Chemical References

• Endotoxins
• Thymus Extracts
• thymostimulin

Topics

• Animals
• Endotoxins (blood)
• Escherichia coli
• Female
• Hepatitis, Animal (drug therapy)
• Liver (pathology)
• Mice
• Thymectomy
• Thymus Extracts (therapeutic use)