Prospective clinical trial on the efficacy of amoxycillin administered twice or four times daily in children with respiratory tract infections.

Abstract

Thirty-four children with upper or lower respiratory tract infections were randomly allocated to receive either a twice daily or four times daily dose of 50 mg amoxycillin/kg body-weight/day. Mean duration of therapy was identical in both groups. Peak and trough antibiotic concentrations were determined. Eradication of bacteria, clinical improvement and side-effects were comparable in both groups.

• Authors: F D Daschner, U Behre, A Dalhoff
• Journal: The Journal of international medical research (J Int Med Res) Vol. 9 Issue 4 Pg. 274-6 ( 1981) ISSN: 0300-0605 [Print] England
• PMID: 7021263 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Amoxicillin

Topics

• Administration, Oral
• Amoxicillin (administration & dosage)
• Bacterial Infections (drug therapy)
• Child
• Child, Preschool
• Clinical Trials as Topic
• Humans
• Infant
• Prospective Studies
• Random Allocation
• Respiratory Tract Infections (drug therapy)