Amoxapine: once versus divided daily doses in neurotic and endogenous depression.

Abstract

In a six-week, double-blind clinical study of 35 hospitalized patients with the diagnoses of endogenous depression (18 patients) and depressive neuroses (17 patients), two dosage schedules of amoxapine were compared. While no statistically significant difference in overall therapeutic and adverse effects between the groups treated with single daily doses and divided daily doses were found by the end of the six weeks investigational period, onset of therapeutic effect was faster in the group treated with single daily doses. There was a significantly greater improvement in Anxiety-Somatization and Sleep Disturbance (HAM-D factors) in the group with depressive neurosis than in the group with endogenous depression.

• Authors: M Ragheb, W H Wilson, T A Ban, J O Brannen
• Journal: The Journal of clinical psychiatry (J Clin Psychiatry) Vol. 42 Issue 8 Pg. 318-21 (Aug 1981) ISSN: 0160-6689 [Print] United States
• PMID: 7019201 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Dibenzoxazepines
• Amoxapine

Topics

• Adult
• Amoxapine (administration & dosage, adverse effects, therapeutic use)
• Clinical Trials as Topic
• Depressive Disorder (drug therapy)
• Dibenzoxazepines (administration & dosage)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Psychiatric Status Rating Scales
• Random Allocation