Calcinosis in dermatomyositis treated with probenecid.

Abstract

Childhood dermatomyositis is frequently complicated by deposition of calcium salts in the soft tissues. This calcinosis represents a major problem, as severe disability may result. Various drugs have been tried to dissolve the calcinosis, but the results of these trials are disappointing. In this article we present a case report of a 9-year-old girl treated with probenecid. This treatment led to a dramatic decrease in subcutaneous and intermuscular calcinosis. The authors call for controlled studies of probenecid treatment in calcinosis.

• Authors: E Skuterud, O A Sydnes, T K Haavik
• Journal: Scandinavian journal of rheumatology (Scand J Rheumatol) Vol. 10 Issue 2 Pg. 92-4 ( 1981) ISSN: 0300-9742 [Print] England
• PMID: 7017918 (Publication Type: Case Reports, Clinical Trial, Journal Article)

Chemical References

• Probenecid

Topics

• Calcinosis (drug therapy, etiology)
• Child
• Clinical Trials as Topic
• Dermatomyositis (complications)
• Female
• Humans
• Probenecid (therapeutic use)