Effect of cyclosporin A upon second-set rejection of rat renal allografts.
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| Abstract |
With the use of a DA to LEW rat renal allograft model, the ability of cyclosporin A to influence a second-set rejection was investigated. Sensitization of LEW rats was accomplished by performing DA to LEW skin grafts 4 to 5 weeks before kidney allografting. Cyclosporin A was given to sensitized rats in doses of 10 or 25 mg/kg/day for 14 days from the time of renal transplantation. Neither dose was nearly as effective in prolonging kidney graft survival in sensitized rats as the 10 mg/kg/day dose was in prolonging kidney graft survival in unsensitized rats. In the 25 mg/kg/day dose, cyclosporin A was capable of suppressing antibody formation to the graft in sensitized recipients despite the presence of donor-specific antibodies at the time of renal transplantation. The 10 mg/kg/day dose of cyclosporin A did not, however, suppress antibody formation after renal transplantation in sensitized recipients. In both sensitized and unsensitized rats cyclosporin A was effective in ameliorating the histological findings of arterial fibrinoid necrosis and glomerular necrosis in the renal allografts. In neither sensitized nor unsensitized rats did cyclosporin A effect the mononuclear cell infiltration of the renal allograft.
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| Authors | W P Homan, J W Fabre, P R Millard, P J Morris |
| Journal | Transplantation (Transplantation) Vol. 30 Issue 5 Pg. 354-7 (Nov 1980) ISSN: 0041-1337 [Print] United States |
| PMID | 7006168 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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