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Efficacy and side effects of chloral hydrate and tryptophan as sleeping aids in psychogeriatric patients.

Abstract
The effects of placebo, L-tryptophan 3 g, and chloral hydrate 500 mg on sleep were studied in 19 nonpsychotic, mildly demented, geriatric inpatients. Only chloral hydrate was more effective in inducing and maintaining sleep than placebo. Neither chloral hydrate not L-tryptophan had any significant side effects, but withdrawal of chloral hydrate was associated with insomnia.
AuthorsM Linnoila, M Viukari, A Numminen, J Auvinen
JournalInternational pharmacopsychiatry (Int Pharmacopsychiatry) Vol. 15 Issue 2 Pg. 124-8 ( 1980) ISSN: 0020-8272 [Print] Switzerland
PMID7002832 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Hypnotics and Sedatives
  • Placebos
  • Chloral Hydrate
  • Tryptophan
Topics
  • Aged
  • Chloral Hydrate (adverse effects, therapeutic use)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Hypnotics and Sedatives (therapeutic use)
  • Mental Disorders (drug therapy)
  • Placebos
  • Sleep (drug effects)
  • Sleep Initiation and Maintenance Disorders (drug therapy)
  • Tryptophan (therapeutic use)

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