Treatment of distal ulcerative colitis (proctosigmoiditis) in relapse: comparison of hydrocortisone enemas and rectal hydrocortisone foam.

Abstract

Thirty patients with distal colitis (proctosigmoiditis) in relapse were randonly allocated to twice daily treatment with traditional aqueous hydrocotrisone enemas (Cortenemas) or a suspension of hydrocortisone in an inert foam base (Colifoam). Each treatment contained the same amount of hydrocortisone. Clinical, sigmoidoscopic, and histological response was assessed after two weeks. Both agents were effective, and broadly similar in terms of objective improvement, but subjective improvement was greater with the foam preparation, and several patients expressed a preference to this mode of treatment.

• Authors: W S Ruddell, R J Dickinson, M F Dixon, A T Axon
• Journal: Gut (Gut) Vol. 21 Issue 10 Pg. 885-9 (Oct 1980) ISSN: 0017-5749 [Print] England
• PMID: 7002739 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• Suspensions
• Hydrocortisone

Topics

• Administration, Topical
• Adult
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Clinical Trials as Topic
• Colitis, Ulcerative (drug therapy, pathology)
• Enema
• Female
• Humans
• Hydrocortisone
• Male
• Middle Aged
• Random Allocation
• Sigmoidoscopy
• Suspensions