[Relationships between clinico-therapeutic parameters and immunological status in patients with lung cancer].

Abstract

150 patients with lung cancer have been studied from the immunological point of view: the two years that elapsed between the study and processing of the data permitted an evaluation of the prognosis in terms of immunology also. This study has been carried out in vivo by means of skin tests (BCG, PPD, Candida, Varidase, CCB, Mumps, BNCB) and in vitro with lymphocyte blastization in the presence of PHA and dependent antibody cytotoxicity. Serum factors which can interfere with lymphocyte cytotoxicity have also been studied. Peri- and intra-tumour lymphocyte infiltration and the lymph node activation stage have been analyzed in patients who underwent surgery. A real depression of the cell mediated immunity observed in the negative response to skin tests has been found. The study of in vitro parameters showed a deficient blast response in 86% of the cases examined, decreased cytotoxicity in 62% and the presence of inhibiting serum factors in 53%. No correlation was observed between positivity to skin tests, normal response to PHA, normal concentration of inhibiting serum factors on the one hand and survival on the other. The only finding which seems to be correlated with survival is lymphocyte infiltration; its peri- and intrastromal presence on the neoplasia may be associated with a significantly better prognosis.

• Authors: G C Roviaro, F Varoli, F Sartori, F Calabrò, F Bortolotti, F Tremolada, G Fattovich, A Cecchetto, P Paruzzolo
• Journal: Minerva medica (Minerva Med) Vol. 71 Issue 25 Pg. 1757-67 (Jun 23 1980) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: Rapporti tra parametri clinico-terapeutici e stato immunitario nel paziente portatore di cancro del polmone. Analisi di 150 casi.
• PMID: 6997779 (Publication Type: Journal Article)

Chemical References

• Antigens
• Dinitrochlorobenzene
• Tuberculin
• Streptodornase and Streptokinase

Topics

• Antigens
• Cytotoxicity Tests, Immunologic
• Dinitrochlorobenzene
• Humans
• Hypersensitivity, Delayed
• Lung Neoplasms (immunology, surgery)
• Lymphocyte Activation
• Mycobacterium bovis
• Prognosis
• Skin Tests
• Streptodornase and Streptokinase
• Tuberculin