A controlled study of diflunisal in sprains and strains.

Abstract

A preliminary double-blind, randomized trial was carried out in general practice to compare the efficacy of treatment with diflunisal (500 mg) twice daily and a combination of dextropropoxyphene (65 mg) plus paracetemol (650 mg) 3-times daily for 3 days in relieving pain associated with strains and sprains. Analysis of the results from 51 patients showed that both treatments were equally effective in releiving spontaneous pain and pain on movement after 1 and 3 days, and there were no differences between the two groups in patients' overall evaluation of treatment or physicians' assessment of therapeutic response. Both treatments were well tolerated during the short-term period of the trial.

• Authors: G V Jaffé, P J Roylance, J J Grimshaw
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 5 Issue 7 Pg. 584-8 ( 1978) ISSN: 0300-7995 [Print] England
• PMID: 699627 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• Biphenyl Compounds
• Acetaminophen
• Dextropropoxyphene

Topics

• Acetaminophen (adverse effects, therapeutic use)
• Adolescent
• Adult
• Age Factors
• Aged
• Analgesics (adverse effects, therapeutic use)
• Biphenyl Compounds (adverse effects, therapeutic use)
• Dextropropoxyphene (adverse effects, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Pain (drug therapy)
• Sprains and Strains (drug therapy)