A comparative study of benoxaprofen and ibuprofen in osteoarthritis in general practice.

Abstract

A total of 120 general practice patients with osteoarthritis of the knee or hip received either benoxaprofen 600 mg mane or ibuprofen 400 mg tid for 4 months in a double-blind, parallel trial. No patients withdrew because of lack of efficacy. Statistically significant differences in favor of benoxaprofen were found for knee flexion and pain relief. A small number of patients withdrew because of gastrointestinal reactions (7 taking benoxaprofen and 6 taking ibuprofen). Skin reactions were commoner with benoxaprofen, which provoked sun sensitivity in 5 patients, none of whom withdrew. Significantly more patients on benoxaprofen (67%) wished to continue therapy than those on ibuprofen (32%).

• Authors: V C Tyson, A Glynne
• Journal: The Journal of rheumatology. Supplement (J Rheumatol Suppl) Vol. 6 Pg. 132-8 ( 1980) ISSN: 0380-0903 [Print] Canada
• PMID: 6993669 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Benzoxazoles
• Propionates
• benoxaprofen
• Alkaline Phosphatase
• Ibuprofen

Topics

• Adult
• Age Factors
• Aged
• Alkaline Phosphatase (blood)
• Anti-Inflammatory Agents (adverse effects, therapeutic use)
• Benzoxazoles (adverse effects, therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Family Practice
• Female
• Gastrointestinal Diseases (chemically induced)
• Humans
• Ibuprofen (adverse effects, therapeutic use)
• Male
• Middle Aged
• Osteoarthritis (drug therapy)
• Propionates (adverse effects, therapeutic use)
• Skin Diseases (chemically induced)
• Time Factors