[Evaluation of nephropathies in children with rheumatoid arthritis and prolonged therapy with salicylates].

Abstract

The study included 18 school-age and adolescent patients with juvenile rheumatoid arthritis who had consumed from 351 to 6393 gm. (average 2813 gm.) as total dose for the control of their disease. All of them underwent a complete physical examination, general laboratory tests and as specific tests of renal function; urinalysis, urine culture, endogenous creatinine clearance, Addis count (red and white cells), sodium and potassium urinary excretion, urinary acidity capacity, administration of ammonium chloride and capacity of urinary concentration following water restriction. Normal results in practically all parameters led to conclude that a clear evidence of nephropathy due to salicylic acid consumption, was not found in any of the patients studied.

• Authors: A C Salazar, E López, R Vargas
• Journal: Boletin medico del Hospital Infantil de Mexico (Bol Med Hosp Infant Mex) 1980 Mar-Apr Vol. 37 Issue 2 Pg. 333-43 ISSN: 0539-6115 [Print] Mexico
• Vernacular Title: Valoración de nefropatía en niños con artritis reumatoide y terapia prolongada con salicilatos.
• PMID: 6990941 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Placebos
• Aspirin

Topics

• Adolescent
• Adult
• Arthritis, Juvenile (drug therapy)
• Aspirin (adverse effects, therapeutic use)
• Child
• Child, Preschool
• Clinical Trials as Topic
• Drug Evaluation
• Female
• Humans
• Kidney Diseases (chemically induced, diagnosis)
• Kidney Function Tests
• Male
• Placebos