Modification of glycosylated haemoglobin concentration during artificial endocrine pancreas treatment of diabetics. Evidence for a short-term effect on HbA 1 (a+b+c) levels.

Abstract

In order to verify whether or not insulin-induced blood glucose control can acutely lower glycosylated haemoglobin levels, HbAI (a+b+c) (HbAI) was measured in 11 diabetics before, during and after 3 days of treatment with an "artificial endocrine pancreas" (Biostator). Initially 5 patients were in fair glycaemic control (group A), while the other 6 showed poor control (group B). HbAI levels decreased significantly after 3 days in both groups A (from 9.6 +/- 0.2% to 8.5 +/- 0.3%, mean +/- SEM, p less than 0.05) and B (from 13.7 +/- 0.2% to 12.6 +/- 0.3%, p less than 0.05). A further HbAI decrease was observed until day 60 following Biostator treatment, during which period glycaemic control improved, as assessed by fasting and post-lunch plasma glucose values and daily glycosuria determined every 10 days. These results suggest that increased HbAI levels may be reversed early by strict blood glucose control during a 3 day period. It is concluded that HbAI levels not only reflect long-term glycaemic control, but also recent acute variations in mean blood glucose values.

• Authors: G Bolli, M G Cartechini, P Compagnucci, F Santeusanio, M Massi-Benedetti, G Calabrese, A Puxeddu, P Brunetti
• Journal: Diabetologia (Diabetologia) Vol. 18 Issue 2 Pg. 125-30 ( 1980) ISSN: 0012-186X [Print] Germany
• PMID: 6988271 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Glycosides
• Insulin
• Hemoglobin A

Topics

• Adolescent
• Adult
• Artificial Organs
• Blood Glucose (analysis)
• Diabetes Mellitus (blood, drug therapy)
• Female
• Glycosides (analysis, blood)
• Glycosuria
• Hemoglobin A (analogs & derivatives, analysis)
• Humans
• Insulin (therapeutic use)
• Islets of Langerhans (physiology)
• Male
• Middle Aged