Abstract |
Transplant teams have been reluctant to accept kidneys preserved with intracellular electrolyte flushing followed by simple cold storage, especially when retrieved by non-transplant surgeons or when preservation time exceeds 24 hours. This study from 1 center is a comparison of 40 primary cadaver kidney grafts preserved with Collins' C2 flushing followed by simple cold storage to 37 primary cadaver kidney grafts preserved with cryoprecipitated plasma on the MOX-100 machine. Cold storage time was 10 to 44.5 hours in the C2 group and 3.5 to 39 hours in the machine-perfused group, with a mean of 23 hours in each group. There was no significant difference between the 2 preservation methods no matter who removed the kidney with respect to 1) the incidence of acute tubular necrosis, 2) the 1-month serum creatinine nadir of surviving grafts and 3) the actuarial graft survivals up to 2 years. Among the 40 C2-preserved kidneys 17 were retrieved by community surgeons and 23 were retrieved by transplant surgeons. Human kidneys removed from beating-heart cadaver donors can be preserved satisfactorily with either Collins' 2 flushing followed by simple cold storage or pulsatile machine perfusion, even when preservation times exceed 24 hours.
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Authors | J M Barry, J B Metcalfe, M A Farnsworth, W M Bennett, C V Hodges |
Journal | The Journal of urology
(J Urol)
Vol. 123
Issue 1
Pg. 14-6
(Jan 1980)
ISSN: 0022-5347 [Print] United States |
PMID | 6985977
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Age Factors
- Cadaver
- Child
- Cold Temperature
- Costs and Cost Analysis
- Creatinine
(blood)
- Humans
- Kidney
- Kidney Transplantation
- Kidney Tubular Necrosis, Acute
(etiology)
- Middle Aged
- Organ Preservation
(methods)
- Perfusion
(methods)
- Time Factors
- Tissue Preservation
(methods)
- Transplantation, Homologous
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