Effective multidrug, multimodality consolidation therapy of adult acute lymphocytic leukemia: a preliminary report.

Abstract

Twelve of 13 adult patients with acute lymphocytic leukemia, acute undifferentiated leukemia, or convoluted T-cell lymphoma (T-cell ALL) who were treated with Adriamycin, vincristine, and prednisone achieved a complete remission. An intensive consolidation regimen was administered. This regimen included Cytosine Arabinoside, L-asparaginase, and multiple courses of CHOP (cyclophosphamide, Adriamycin, vincristine, and prednisone). In addition, cranial irradiation and intrathecal methotrexate were administered. By actuarial estimate, 81% of previously untreated patients who achieved a complete remission will remain in remission for more than two years.

• Authors: R S Stein, J M Flexner, R D Collins
• Journal: Cancer (Cancer) Vol. 49 Issue 5 Pg. 846-9 (Mar 01 1982) ISSN: 0008-543X [Print] United States
• PMID: 6977407 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Vincristine
• Doxorubicin
• Prednisone

Topics

• Adult
• Antineoplastic Agents (administration & dosage, adverse effects)
• Doxorubicin (administration & dosage)
• Drug Evaluation
• Drug Therapy, Combination
• Female
• Humans
• Leukemia, Lymphoid (drug therapy, pathology, radiotherapy)
• Lymphoma (drug therapy)
• Male
• Middle Aged
• Prednisone (administration & dosage)
• Prognosis
• T-Lymphocytes
• Vincristine (administration & dosage)