Trenimon-induced SCEs and structural chromosomal aberrations in early- and late-dividing lymphocytes.

Abstract

In cultures of human peripheral lymphocytes the frequencies of Trenimon-induced SCEs in second post-treatment metaphases and of structural chromosomal aberrations in first, second and third post-treatment metaphases were clearly lower at late as compared with early fixation times. These results, which are discussed, indicate that T cells (early dividing) are more sensitive with respect to the induction of SCEs and structural chromosomal aberrations by Trenimon as compared with B cells (late dividing).

• Authors: L Riedel, G Obe
• Journal: Mutation research (Mutat Res) Vol. 73 Issue 1 Pg. 125-31 (Nov 1980) ISSN: 0027-5107 [Print] Netherlands
• PMID: 6973084 (Publication Type: Journal Article)

Chemical References

• Triaziquone

Topics

• Adult
• B-Lymphocytes (drug effects)
• Cell Cycle
• Cell Division
• Chromosome Aberrations
• Crossing Over, Genetic (drug effects)
• Humans
• Lymphocytes (drug effects)
• Male
• Metaphase
• Sister Chromatid Exchange (drug effects)
• T-Lymphocytes (drug effects)
• Time Factors
• Triaziquone (pharmacology)