HLA-DR3 in dermatitis herpetiformis.

Abstract

Twenty-one patients with dermatitis herpetiformis were typed for HLA-ABC and -DR determinants. The incidence of HLA-AI, -B8 and -DR3 antigens was found to be significantly higher (P: = 10(-3), less than 10(-6) and less than 10(-6), respectively) among patients with dermatitis herpetiformis than among the normal population. HLA-DR3 was found in 85.7% of patients, HLA-B8 in 66.7% and HLA-AI in 61.9% only. These results indicate that HLA-DR3 is the antigen primarily associated in dermatitis herpetiformis and the latter antigens (HLA-AI and -B8) are present in increased incidence, probably due to the known linkage disequilibrium of these antigens with HLA-DR3.

• Authors: H Pehamberger, K Holubar, W R Mayr
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 104 Issue 3 Pg. 321-4 (Mar 1981) ISSN: 0007-0963 [Print] England
• PMID: 6971119 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DR3 Antigen
• Histocompatibility Antigens Class II

Topics

• Adolescent
• Adult
• Aged
• Child
• Dermatitis Herpetiformis (immunology)
• Female
• HLA-DR3 Antigen
• Histocompatibility Antigens Class II (analysis)
• Histocompatibility Testing
• Humans
• Male
• Middle Aged