Abstract |
In a small open dose-finding study the i.v. dose of ICI 35 868 required to induce anaesthesia in healthy adults was 2 mg kg-1. Comparison of this dose with Althesin 0.05 ml kg-1 for i.v. induction, both injected over 30 s suggests that they have similar effects on heart rate, arterial pressure and breathing. The mean times to loss of eyelash reflex were 57 +/- SD 10.1 s (ICI 35 868) and 46 +/- 3.9s ( Althesin). The new drug was associated with pain and discomfort on injection in seven of 10 patients, but with less involuntary movement than occurred with Althesin.
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Authors | K M Rogers, K M Dewar, T D McCubbin, A A Spence |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 52
Issue 8
Pg. 807-10
(Aug 1980)
ISSN: 0007-0912 [Print] England |
PMID | 6968567
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Anesthetics
- Phenols
- Alfaxalone Alfadolone Mixture
- Propofol
|
Topics |
- Adolescent
- Adult
- Alfaxalone Alfadolone Mixture
(administration & dosage, pharmacology)
- Anesthesia, Intravenous
(methods)
- Anesthetics
(administration & dosage, pharmacology)
- Double-Blind Method
- Drug Administration Schedule
- Drug Evaluation
- Hemodynamics
(drug effects)
- Humans
- Middle Aged
- Phenols
(administration & dosage, pharmacology)
- Propofol
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