[Long-term treatment of schizophrenic patients with leponex (clozapine)].

Abstract

The authors studied a prolonged (3--5 years) use of leponex in 23 patients with the most progressive forms of schizophrenia (hebephrenic, paranoid and close to them attack-like). The study included the influence on the frequency and duration of relapses, on the dynamics of the so-called productive and negative disorders and social adaptation. The achieved data indicate that leponex possesses certain advantages compared to other neuroleptical drugs in prolonged maintenance therapy. Leponex has a rather "universal" psychopharmacological effect which includes a capability of arresting acute psychoses, exerts a psychoregulating influence on the general behaviour, contacts and socio-working adaptation, distinctly alleviates the clinical signs and frequency of relapses. Due to the absence of motor disturbances and minimum of other side-effects leponex is quite convenient for prolonged use and promotes a higher quality of remissions.

• Authors: G P Panteleeva, M Ia Tsutsul'kovskaia, M B Mazurskiĭ, Iu M Danilenko
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 78 Issue 8 Pg. 1247-56 ( 1978) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Dlitel'noe lechenie leponeksom (klozapinom) bol'nykh schizofrenieĭ.
• PMID: 696118 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dibenzazepines
• Clozapine

Topics

• Adult
• Chronic Disease
• Clozapine (administration & dosage)
• Dibenzazepines (administration & dosage)
• Female
• Humans
• Male
• Middle Aged
• Recurrence
• Schizophrenia (drug therapy)
• Schizophrenia, Disorganized (drug therapy)
• Schizophrenia, Paranoid (drug therapy)
• Social Adjustment
• Syndrome
• Time Factors