Abstract |
In six children in the first remission after treatment of acute lymphoblastic leukemia (ALL) the constitutive activity of aryl hydrocarbon (benzo-[alpha] pyrene) hydroxylase (AHH) (0.14 +/- 0.04 U, i.e. pmol of 3- OH-benzo[alpha] pyrene x 10(-6) cells x min-1) in phytohaemoagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) was significantly lower (P 0.05) than the constitutive activities in the parents of the children (0.25 +/- 0.09 U) and in the control adult group (0.26 +/- 0.09 U). In methylcholanthrene (MC)-induced activities of AHH no significant differences were observed between the above groups.
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Authors | A L Pawlak, K Wiktorowicz, B Duczmal-Szewczuk |
Journal | Cancer letters
(Cancer Lett)
Vol. 17
Issue 1
Pg. 95-9
(Oct 1982)
ISSN: 0304-3835 [Print] Ireland |
PMID | 6960973
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Phytohemagglutinins
- Methylcholanthrene
- Aryl Hydrocarbon Hydroxylases
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Topics |
- Adult
- Aryl Hydrocarbon Hydroxylases
(metabolism)
- Cell Transformation, Neoplastic
(metabolism)
- Cells, Cultured
- Child, Preschool
- Humans
- Leukemia, Lymphoid
(metabolism, therapy)
- Lymphocyte Activation
- Lymphocytes
(enzymology, metabolism)
- Methylcholanthrene
(pharmacology)
- Phytohemagglutinins
(pharmacology)
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