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Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis.

Abstract
Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine. All patients had previous mucocutaneous reactions to chrysotherapy. Manifestations included pleurisy in five of six patients, rashes in three, nephritis in two, and neurologic disturbances in two; lupus erythematosus cells were found in five patients, antinuclear antibodies in all six, antideoxyribonucleic acid in three, positive Coombs' test results for three patients, and low C4 complement in five of the six. Symptoms were slow to resolve after penicillamine treatment was discontinued, and four of the patients needed corticosteroid therapy. A higher frequency than expected of HLA A 11 in three patients and B 15 in five patients was seen.
AuthorsA Chalmers, D Thompson, H E Stein, G Reid, A C Patterson
JournalAnnals of internal medicine (Ann Intern Med) Vol. 97 Issue 5 Pg. 659-63 (Nov 1982) ISSN: 0003-4819 [Print] United States
PMID6958210 (Publication Type: Case Reports, Journal Article)
Chemical References
  • HLA Antigens
  • Histocompatibility Antigens Class II
  • Penicillamine
Topics
  • Adult
  • Aged
  • Arthritis, Rheumatoid (drug therapy, immunology)
  • Drug Hypersensitivity (etiology)
  • Female
  • HLA Antigens (analysis)
  • Histocompatibility Antigens Class II (analysis)
  • Humans
  • Lupus Erythematosus, Systemic (chemically induced, immunology)
  • Middle Aged
  • Penicillamine (adverse effects, therapeutic use)

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