Animal models for the study of cancer-induced anorexia.

Abstract

Walker carcinoma 256/B transplanted sc in CD-COBS rats induce a decrease of food intake when the tumor size is less than 5% of the body weight. This anorexia is accompanied by a decrease of the adipose tissue and, to a lesser extent, of muscular tissue. The mechanism involved in cancer-induced anorexia seems to be different from that of classic centrally acting anorectic agents. Among the drugs tested to counteract this anorexia only cyproheptadine shows a modest effect. Cyclophosphamide reduces tumor growth and prevents decrease in food intake. It is suggested that Walker carcinoma 256/B may be a useful animal model to study problems related to cancer-induced anorexia and cachexia.

• Authors: S Garattini, A Guaitani
• Journal: Cancer treatment reports (Cancer Treat Rep) Vol. 65 Suppl 5 Pg. 23-35 ( 1981) ISSN: 0361-5960 [Print] United States
• PMID: 6955017 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Appetite Depressants
• Cyclophosphamide

Topics

• Animals
• Anorexia (etiology, prevention & control)
• Appetite Depressants (pharmacology)
• Body Weight
• Cachexia (etiology)
• Carcinoma 256, Walker (complications, drug therapy)
• Cyclophosphamide (therapeutic use)
• Eating
• Feeding and Eating Disorders (etiology)
• Humans
• Male
• Mice
• Mice, Inbred CBA
• Neoplasms, Experimental (complications)
• Rats
• Rats, Inbred Strains