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"Spontaneous" erythroid progenitor cells in the circulation and monosomy 7 in juvenile chronic myelogenous leukemia.

Abstract
Cytogenetic examination of bone marrow cells from two patients with juvenile chronic myelogenous leukemia (JCML) showed a monosomy 7. Peripheral blood from these two children was found to contain large numbers of cells capable of erythroid colony formation in tissue culture without added erythropoietin. We conclude that erythroid progenitor cells are part of the malignant clone in JCML.
AuthorsM Symann, C de Montpellier, J Ninane, H Van den Berghe
JournalCancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 6 Issue 2 Pg. 183-5 (Jun 1982) ISSN: 0165-4608 [Print] United States
PMID6955004 (Publication Type: Case Reports, Journal Article)
Topics
  • Child, Preschool
  • Chromosome Aberrations
  • Chromosomes, Human, 6-12 and X
  • Erythrocytes (pathology)
  • Hematopoiesis
  • Humans
  • Leukemia, Myeloid (blood, genetics)
  • Male

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