HLA-DR specificities among Japanese with several autoimmune diseases.

Abstract

HLA-A, -B, -C, and -DR antigens were determined in order to study the association of HLA in Japanese patients with several autoimmune diseases, hypertrophic cardiomyopathy, and Hodgkin's disease. The frequency of HLA-DR4 was significantly increased in the patients with rheumatoid arthritis, juvenile-onset insulin-dependent diabetes mellitus (IDDM) and hypertrophic obstructive cardiomyopathy. In this study, no significant associations with A, B, or C specificities were observed except BW22 in IDDM. In contrast, the negative association with HLA-DR2 was observed in Hashimoto's thyroiditis, pemphigus vulgaris and hypertrophic non-obstructive cardiomyopathy.

• Authors: T Sakurami, Y Ueno, Y Iwaki, M S Park, P I Terasaki, H Saji
• Journal: Tissue antigens (Tissue Antigens) Vol. 19 Issue 2 Pg. 129-33 (Feb 1982) ISSN: 0001-2815 [Print] England
• PMID: 6954729 (Publication Type: Comparative Study, Journal Article)

Chemical References

• HLA Antigens
• HLA-DR Antigens
• Histocompatibility Antigens Class II

Topics

• Arthritis, Rheumatoid (immunology)
• Autoimmune Diseases (immunology)
• Cardiomyopathy, Hypertrophic (immunology)
• Diabetes Mellitus, Type 1 (immunology)
• Genetic Linkage
• Graves Disease (immunology)
• HLA Antigens
• HLA-DR Antigens
• Histocompatibility Antigens Class II (genetics)
• Humans
• Japan
• Pemphigus (immunology)
• Thyroiditis, Autoimmune (immunology)