HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Gaseous formaldehyde and hydrogen chloride induction of nasal cancer in the rat.

Abstract
The carcinogenic response to the combined and separate exposures to formaldehyde (HCHO) and hydrochloric acid (HCl) was investigated in male inbred SD rats. The rats were exposed to gaseous HCHO, 14 ppm, and HCl, 10 ppm, in two experiments. In one experiment the gases were premixed at high concentrations before being diluted in the exposure chamber air to maximize the formation of the carcinogen bis(chloromethyl)ether (BCME). In the second experiment exposure was repeated to HCl and HCHO premixed at high concentrations, and not premixed (to minimize BCME formation), as well as to HCHO alone and HCl alone. The second experiment is being reported on at an interim stage. HCHO alone induced squamous carcinomas of the nasal cavity as did the combined exposures to HCHO and HCl. No carcinogenic response was observed with HCl alone. HCHO accounted for most, if not all, of the carcinogenic activity of the mixture of HCHO-HCl.
AuthorsR E Albert, A R Sellakumar, S Laskin, M Kuschner, N Nelson, C A Snyder
JournalJournal of the National Cancer Institute (J Natl Cancer Inst) Vol. 68 Issue 4 Pg. 597-603 (Apr 1982) ISSN: 0027-8874 [Print] United States
PMID6951075 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Gases
  • Formaldehyde
  • Bis(Chloromethyl) Ether
  • Hydrochloric Acid
Topics
  • Animals
  • Bis(Chloromethyl) Ether (toxicity)
  • Body Weight
  • Drug Interactions
  • Formaldehyde (toxicity)
  • Gases
  • Humans
  • Hydrochloric Acid (toxicity)
  • Male
  • Nasal Cavity
  • Nasal Mucosa (drug effects)
  • Nose Neoplasms (chemically induced, mortality)
  • Rats
  • Rats, Inbred Strains
  • Risk

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: