Successful treatment of murine muscular dystrophy with the proteinase inhibitor leupeptin.

Abstract

Mice with genetic muscular dystrophy were treated with intraperitoneal injections of the proteinase inhibitor leupeptin, beginning before the onset of weakness. A significant number of the treated animals failed to develop histological evidence of dystrophy, compared with controls. Leupeptin treatment prevented (or delayed) the onset of muscular dystrophy in this experiment.

• Authors: J H Sher, A Stracher, S A Shafiq, J Hardy-Stashin
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 78 Issue 12 Pg. 7742-4 (Dec 1981) ISSN: 0027-8424 [Print] United States
• PMID: 6950412 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Leupeptins
• Oligopeptides

Topics

• Animals
• Leupeptins (administration & dosage, therapeutic use)
• Mice
• Muscular Dystrophy, Animal (drug therapy, genetics, pathology)
• Oligopeptides (therapeutic use)
• Time Factors