Netilmicin in the treatment of severe or complicated urinary tract infections.

Abstract

Netilmicin is a new aminoglycoside antibiotic with pharmacological similarities to gentamicin, tobramycin and sisomicin. Fourteen of 15 patients with a severe or complicated urinary tract infection were cured by treatment with a seven day course of netilmicin. In one patient the infecting organism was not eradicated. No significant side effects were noted and no ototoxicity was detected. Four patients had a significant, but reversible, deterioration in renal function as defined by an increase in the plasma creatinine of 0.03 mmol/l or greater. Work in experimental animals has shown netilmicin to be significantly less ototoxic and nephrotoxic than other clinically available aminoglycosides. If this finding is confirmed in large-scale comparative trials in man, netilmicin should prove a most useful and effective new antibiotic for the treatment of severe gram-negative sepsis.

• Authors: B A Peddie, R R Bailey, E Blake, M J Summerfield
• Journal: The New Zealand medical journal (N Z Med J) Vol. 91 Issue 660 Pg. 378-81 (May 28 1980) ISSN: 0028-8446 [Print] New Zealand
• PMID: 6931321 (Publication Type: Journal Article)

Chemical References

• Gentamicins
• Netilmicin
• Creatinine

Topics

• Adult
• Aged
• Creatinine (blood)
• Female
• Gentamicins (therapeutic use)
• Glomerular Filtration Rate
• Humans
• Kidney (physiopathology)
• Male
• Middle Aged
• Netilmicin (adverse effects, therapeutic use)
• Urinary Tract Infections (drug therapy)