HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Induced acute non-lymphocytic leukemia following long-term chemotherapy: a study of 20 cases.

Abstract
Twenty individuals developed acute non-lymphocytic leukemia (ANLL) following long-term chemotherapy for other disorders. The primary disorders included non-Hodgkin's lymphoma (five), Hodgkin's disease (five), carcinoma (four), multiple myeloma (three), chronic leukemia (two), and rheumatoid arthritis. Leukemia developed from 11-132 months (mean approximately 60 months) following institution of chemotherapy and all cases have occurred since 1974. Pre-leukemic cytopenias were present in 15 individuals. Fifteen of the 20 patients had chromosome analyses and 14 were abnormal. The leukemia was invariably refractory to chemotherapy with a median survival of only two months. Of the patients autopsied, only one individual had any evidence of the primary malignancy. This study illustrates the need for surveillance for secondary ANLL following long-term chemotherapy with/without radiotherapy. Duration of optimal chemotherapy for the primary disease must be determined by control trials and weighed against the risk of developing a secondary leukemia.
AuthorsS B Kapadia, J R Krause, L D Ellis, S F Pan, N Wald
JournalCancer (Cancer) Vol. 45 Issue 6 Pg. 1315-21 (Mar 15 1980) ISSN: 0008-543X [Print] United States
PMID6928396 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
Topics
  • Adult
  • Aged
  • Antineoplastic Agents (adverse effects)
  • Chromosome Aberrations
  • Female
  • Humans
  • Leukemia, Lymphoid (drug therapy)
  • Leukemia, Myeloid, Acute (chemically induced, genetics)
  • Lymphoma (drug therapy)
  • Male
  • Middle Aged
  • Multiple Myeloma (drug therapy)
  • Neoplasms (drug therapy)
  • Neoplasms, Multiple Primary (chemically induced, genetics)
  • Preleukemia (chemically induced, genetics)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: