Abstract |
The isolation and characterization of cyanogen bromide peptides derived from the human gingival collagen of patients with chronic periodontitis revealed the presence of both Type I and Type III collagens in this tissue. The amount of TYPE III collagen, however, was found to be lower than that in normal gingival tissue. In addition, a non-collagenous protein fraction, accounting for approximately 20% of the insoluble matrix, was relatively rich in acidic, hydrophobic, and hydroxy-containing amino acids. Amino acid analysis, likewise, revealed qualitative and quantitative differences between the normal and diseased tissues.
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Authors | O Hammouda, M Seif Sr, B Brinkley, M K Dabbous, J Jurand |
Journal | Journal of dental research
(J Dent Res)
Vol. 59
Issue 1
Pg. 17-22
(Jan 1980)
ISSN: 0022-0345 [Print] United States |
PMID | 6927981
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Amino Acids
- Peptides
- Tropocollagen
- Threonine
- Collagen
- Valine
- Cyanogen Bromide
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Topics |
- Adult
- Amino Acids
(analysis)
- Chromatography, DEAE-Cellulose
- Collagen
(isolation & purification)
- Cyanogen Bromide
- Gingiva
(analysis)
- Humans
- Middle Aged
- Peptides
(isolation & purification)
- Periodontitis
(metabolism)
- Threonine
(isolation & purification)
- Tropocollagen
(isolation & purification)
- Valine
(isolation & purification)
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