Studies on the experimental chemotherapy of Angiostrongylus malaysiensis infection in rats with mebendazole and levamisole.

Abstract

The effect of levamisole hydrochloride and mebendazole on Angiostrongylus malaysiensis infection in albino rats was studied. Animals at different stages of infection were treated with various oral doses of levamisole and mebendazole with the aim of finding an effective treatment regime. Levamisole was most effective for treating rats seven days after infection but its efficacy dropped as infection progressed. Mebendazole given at a dose of 1 mg/kg for five days was more effective against early larval stages (97.39% efficacy). At 5 mg/kg for five days mebendazole was more effective than levamisole against all stages of the infection.

• Authors: S Ambu, B H Kwa, J W Mak
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) Vol. 76 Issue 4 Pg. 458-62 ( 1982) ISSN: 0035-9203 [Print] England
• PMID: 6926760 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Benzimidazoles
• Levamisole
• Mebendazole

Topics

• Angiostrongylus
• Animals
• Benzimidazoles (therapeutic use)
• Dose-Response Relationship, Drug
• Levamisole (therapeutic use)
• Mebendazole (therapeutic use)
• Nematode Infections (drug therapy)
• Rats
• Time Factors