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Treatment of antibiotic-associated pseudomembranous colitis with cholestyramine resin.

Abstract
Pseudomembranous colitis (PMC) is an infrequent but serious complication of oral and intravenous antibiotic therapy. Twelve patients with antibiotic-associated PMC, documented by sigmoidoscopy and rectal biopsy, were treated with cholestyramine resin. The mean time from the institution of therapy to cessation of diarrhea was 2.1 days. The response interval bore no relationship to the time symptoms were present prior to therapy. Complete resolution of sigmoidoscopic and histologic evidence of PMC usually accompanied or followed cessation of diarrhea. Obstipation was reported in 5 of 12 patients as a side effect of cholestyramine treatment. Therapy should be continued for up to five days after cessation of diarrhea to prevent recurrence of active PMC. Cholestyramine resin is shown to be an effective treatment for antibiotic-associated PMC.
AuthorsE W Kreutzer, F D Milligan
JournalThe Johns Hopkins medical journal (Johns Hopkins Med J) Vol. 143 Issue 3 Pg. 67-72 (Sep 1978) ISSN: 0021-7263 [Print] United States
PMID691920 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Cholestyramine Resin
  • Clindamycin
Topics
  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents (adverse effects)
  • Child
  • Cholestyramine Resin (therapeutic use)
  • Clindamycin (adverse effects)
  • Enterocolitis, Pseudomembranous (chemically induced, drug therapy, pathology)
  • Female
  • Humans
  • Male
  • Middle Aged

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