Subchronic toxicity study in rats fed gum karaya.

Gum karaya was given to groups of 15 rats of each sex at levels of 0 (control), 0.2, 1 or 5% (w/w) in the diet for 13 wk. An increase in faecal bulk was seen in all treated groups throughout the study. There was a decrease in weight-gain at the highest dietary level (significant only in the females), which was associated with a marginal reduction in food-conversion efficiency. Males given 1 or 5% drank more than the controls and a transient increase in water intake was seen in females given the highest level. The no-untoward-effect level from this study was 5% (w/w) of the diet, providing a mean intake of about 4 g karaya gum/kg body weight/day.
AuthorsP J Taupin, D M Anderson
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 20 Issue 5 Pg. 513-7 (Oct 1982) ISSN: 0278-6915 [Print] ENGLAND
PMID6890505 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Polysaccharides
  • Karaya Gum
  • Animals
  • Body Weight (drug effects)
  • Diet
  • Drinking Behavior (drug effects)
  • Feeding Behavior (drug effects)
  • Female
  • Karaya Gum (toxicity)
  • Male
  • Organ Size (drug effects)
  • Polysaccharides (toxicity)
  • Rats
  • Rats, Inbred Strains

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