Lipoprotein lipase and hepatic lipase activity after heparin administration in abetalipoproteinemia and hypobetalipoproteinemia.

Abstract

The purpose of this study was to examine whether an absence of triglyceride-rich lipoproteins (chylomicrons and very-low-density lipoproteins) in plasma is associated with any changes in the enzyme activity of lipoprotein lipase or hepatic lipase after heparin administration. To study this, the activities of hepatic lipase and lipoprotein lipase were determined in control subjects, in two patients with heterozygous hypobetalipoproteinemia, and in three patients with phenotypic abetalipoproteinemia after administration of heparin. Both enzymes showed normal activity in the patients with hypobetalipoproteinemia, but showed consistently reduced activity in the patients with abetalipoproteinemia. Hepatic lipase activity in plasma samples from these three patients obtained 15 minutes after intravenous injection of heparin was 55%, 87%, and 46% of that of the controls, whereas corresponding values in plasma samples obtained 30 minutes after heparin were 47%, 70%, and 57%, respectively. Lipoprotein lipase activity in the three patients with abetalipoproteinemia was 46%, 29%, and 34% of that of the controls in the samples obtained 15 minutes after heparin injection, whereas the values obtained after 30 minutes were 53%, 64%, and 47% of that of the controls. We conclude that an inherent absence of triglyceride-rich lipoproteins, as occurs in abetalipoproteinemia, is associated with reduced enzyme activity of both hepatic lipase and lipoprotein lipase in plasma after heparin administration.

• Authors: D R Illingworth, S S Alam, N A Alam
• Journal: Metabolism: clinical and experimental (Metabolism) Vol. 32 Issue 9 Pg. 869-73 (Sep 1983) ISSN: 0026-0495 [Print] United States
• PMID: 6888269 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Heparin
• Lipase
• Lipoprotein Lipase

Topics

• Abetalipoproteinemia (blood, enzymology)
• Adolescent
• Adult
• Child
• Female
• Heparin (pharmacology)
• Humans
• Hypobetalipoproteinemias (blood, enzymology)
• Hypolipoproteinemias (enzymology)
• Lipase (metabolism)
• Lipoprotein Lipase (blood)
• Liver (enzymology)
• Male