A quantitative in vitro study of fibroblast and endothelial cell migration in response to serum and wound fluid.

Abstract	Chemoattractant activity for irradiated and nonirradiated rabbit skin fibroblast and bovine aortic arch endothelial cells was assayed in rabbit wound fluid and sera using a modification of the agarose well method originally described for polymorphonuclear leukocytes. Both serum and wound fluid contained chemoattractants for fibroblasts and endothelial cells. Fibroblast migration was decreased by 70 to 80% when the serum or wound fluid was heated to 56 degrees C for 30 min while endothelial cell migration was reduced by 50 to 60%. Platelet-poor plasma-derived serum had no directive effect on the migration of either cell type.
Authors	S U Orredson, D R Knighton, H Scheuenstuhl, T K Hunt
Journal	The Journal of surgical research (J Surg Res) Vol. 35 Issue 3 Pg. 249-58 (Sep 1983) ISSN: 0022-4804 [Print] United States
PMID	6887846 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Topics	Animals Blood Physiological Phenomena Body Fluids (physiology) Cattle Cell Division (radiation effects) Cell Movement (radiation effects) Endothelium (cytology, physiology) Fibroblasts (physiology) Hot Temperature Kinetics Rabbits Wound Healing

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