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A new model of bone infection used to evaluate the efficacy of antibiotic-impregnated polymethylmethacrylate cement.

Abstract
An animal model of bone infection was designed for evaluation of the benefits of adding antibiotics to polymethylmethacrylate (PMMA) cement. Femora of New Zealand albino rabbits were exposed at the knee; the medullary canals were entered and the contents aspirated. A known number of bacteria was added to each femur before it was filled with either normal Surgical Simplex P bone cement or Surgical Simplex P antibiotic bone cement. The presence or absence of bone infection was documented by quantitative bacteriologic, roentgenographic, and histologic techniques. Simplex antibiotic bone cement prevented infection, even in the presence of 10(7) bacteria. The effectiveness of the antibiotic bone cement was correlated with the rapid release of high levels of erythromycin (14.1 micrograms/g) and colistin (11.3 micrograms/g) specifically at the site of bacterial contamination.
AuthorsG T Rodeheaver, D Rukstalis, M Bono, W Bellamy
JournalClinical orthopaedics and related research (Clin Orthop Relat Res) Issue 178 Pg. 303-11 (Sep 1983) ISSN: 0009-921X [Print] United States
PMID6883865 (Publication Type: Journal Article)
Chemical References
  • Bone Cements
  • Gentamicins
  • Methylmethacrylates
  • gentamicin-polymethylmethacrylate bead
  • Erythromycin
  • Colistin
Topics
  • Animals
  • Bone Cements (therapeutic use)
  • Colistin (administration & dosage, analysis)
  • Drug Therapy, Combination
  • Erythromycin (administration & dosage, analysis)
  • Femur (analysis)
  • Gentamicins (therapeutic use)
  • Methylmethacrylates (therapeutic use)
  • Osteitis (prevention & control)
  • Rabbits

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