[Efficacy of paromomycin sulfate in the elimination of Diphyllobothrium species and Taenia saginata in clinical cases].

Abstract

Recently it has been known that paromomycin sulfate had marked anthelmintic activity against some species of tapeworms. In this investigation, paromomycin sulfate was used for treating 6 cases of diphyllobothriasis and 1 case of Taenia saginata infection. Paromomycin sulfate was administered orally in a single dose or 2 divided doses of 40--60 mg/kg, being followed by a purge about 1.5 hours later. Strobila or fragments of proglottids were expelled from 5 cases, of which only 1 scolex was found in a case of infection with marine species of Diphyllobothrium. In 1 case of diphyllobothriasis no worm or worm-fragment was found in the stool even after the second challenge of treatment. Nevertheless follow-up examination for more than 1 month showed no evidence of remaining infection in all cases. Transient dizziness was observed in only 1 case, disappearing within about 30 minutes. Serum- and urine-examinations detected no abnormal signs in all cases excepting 1 case of diphyllobothriasis with suspected hepatitis. It was concluded that paromomycin sulfate is effective therapeutic agent for the treatment of taeniasis and diphyllobothriasis including marine species.

• Authors: S Yazaki, S Takeuchi, J Maejima, S Fukumoto, H Kamo, Y Sakaguchi
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 36 Issue 3 Pg. 638-43 (Mar 1983) ISSN: 0368-2781 [Print] Japan
• PMID: 6876373 (Publication Type: English Abstract, Journal Article)

Chemical References

• Paromomycin

Topics

• Adult
• Animals
• Child
• Child, Preschool
• Diphyllobothriasis (drug therapy)
• Drug Evaluation
• Female
• Humans
• Male
• Middle Aged
• Paromomycin (adverse effects, pharmacology, therapeutic use)
• Taenia (drug effects)
• Taeniasis (drug therapy)