A case of IgA nephropathy with an unusual response to corticosteroid and immunosuppressive therapy.

Abstract

We report a case of IgA nephropathy that presented with nephrotic syndrome without hematuria. Renal biopsy revealed typical features of IgA nephropathy on light microscopy, immunofluorescence microscopy, and electron microscopy. A dramatic response occurred on corticosteroid and immunosuppressive therapy, characterized by clearance of proteinuria and a fall of serum IgA level to normal. The absence of hematuria and a response to therapy are distinctly unusual features of IgA nephropathy. This case represents a variant of IgA nephropathy associated with a nephrotic syndrome that resembles nephrotic syndrome with minimal change lesion in its responsiveness to immunosuppressive therapy.

• Authors: K Abreo, S F Wen
• Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation (Am J Kidney Dis) Vol. 3 Issue 1 Pg. 54-7 (Jul 1983) ISSN: 0272-6386 [Print] United States
• PMID: 6869370 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin A
• Cyclophosphamide
• Prednisone

Topics

• Adult
• Cyclophosphamide (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Glomerulonephritis (complications, drug therapy, immunology)
• Humans
• Immunoglobulin A (immunology)
• Male
• Nephrotic Syndrome (etiology)
• Prednisone (administration & dosage, therapeutic use)