CCNU toxicity after an overdose in a patient with Hodgkin's disease. Effects on colony-forming cells (CFU-C) and colony-stimulating activity (CSA).

Abstract

An overdose of CCNU (600 mg over a 15-d period) was unintentionally ingested by a patient with advanced Hodgkin's disease subjected to combination chemotherapy. A severe bone marrow depression occurred 3 weeks after the start of the CCNU treatment. The nadir of the platelet count was reached after 4 weeks and that of the granulocyte count after 5 weeks. At the nadir of the white blood cell count, colony-forming cells (CFU-C) were found in significantly reduced numbers in the bone marrow, and were not found at all in the peripheral blood; the amount of colony-stimulating activity (CSA) produced by peripheral blood cells was reduced. However, the cells producing CSA recovered earlier than the CFU-C, and the CSA peak value was reached about 1 week before the peak value for CFU-C in the bone marrow. Thus, in vivo CSA-producing cells appeared to be more resistant to CCNU than were CFU-C, and their recovery appeared to be a prerequisite for the recovery of CFU-C and myelopoietic cells.

• Authors: P Hörnsten, B Sundman-Engberg, G Gahrton, B Johansson
• Journal: Scandinavian journal of haematology (Scand J Haematol) Vol. 31 Issue 1 Pg. 9-14 (Jul 1983) ISSN: 0036-553X [Print] Denmark
• PMID: 6867612 (Publication Type: Case Reports, Journal Article)

Chemical References

• Nitrosourea Compounds
• Lomustine

Topics

• Animals
• Colony-Forming Units Assay
• Dogs
• Granulocytes (drug effects)
• Hematopoietic Stem Cells (drug effects)
• Hodgkin Disease (drug therapy)
• Humans
• Leukocyte Count
• Lomustine (poisoning)
• Male
• Middle Aged
• Monocytes (drug effects)
• Nitrosourea Compounds (poisoning)
• Platelet Count