Work in progress: intra-arterial P-32 chromic phosphate for prevention of postoperative liver metastases in high-risk colorectal cancer patients.

Abstract

Eight patients with locally extensive colorectal cancer were treated with colloidal P-32 chromic phosphate via the superior mesenteric artery following resection to prevent development of liver metastases. Less than 2% of the injected dose was found in the right atrial blood following the first pass through the liver and less than 1% in the urine. Therapy was tolerated well by all patients, with no acute complications. Long-term follow-up is needed to determine the effect of P-32 on the liver and the frequency of hepatic metastases.

• Authors: R V Mantravadi, D G Spigos, S M Karesh, D G Pavel, E G Grady, V Capek
• Journal: Radiology (Radiology) Vol. 148 Issue 2 Pg. 555-9 (Aug 1983) ISSN: 0033-8419 [Print] United States
• PMID: 6867356 (Publication Type: Journal Article)

Chemical References

• Chromium Compounds
• Phosphates
• Chromium
• chromic phosphate

Topics

• Adenocarcinoma (prevention & control, secondary, surgery)
• Chromium (administration & dosage, therapeutic use)
• Chromium Compounds
• Colonic Neoplasms (surgery)
• Humans
• Liver Neoplasms (drug therapy, prevention & control)
• Phosphates (administration & dosage, therapeutic use)
• Rectal Neoplasms (surgery)
• Risk