[Comparative study of the activity of anti-arrhythmia agents in calcium chloride-induced arrhythmia in mice].

Abstract	Calcium chloride (280 mg/kg intravenously) provokes arrhythmia, heart fibrillation and death of mice. Pretreatment with isoptin, etmozine, lidocaine, trimecaine, quinidine and novocainamide prevents rhythm disorders and animals' death. Isoptin, etmozine, lidocaine and trimecaine have been found the most effective. Atropine does not produce any protective action. The simplicity and availability of the method described enables one to apply it as a model for search of new antiarrhythmic drugs.
Authors	V V Gorbunova, N P Gorbunov
Journal	Farmakologiia i toksikologiia (Farmakol Toksikol) 1983 May-Jun Vol. 46 Issue 3 Pg. 48-50 ISSN: 0014-8318 [Print] Russia (Federation)
Vernacular Title	Sravnitel'noe izuchenie aktivnosti antiaritmicheskikh sredstv pri khloridkal'tsievoĭ aritmii u mysheĭ.
PMID	6861988 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References	Anti-Arrhythmia Agents Calcium Chloride
Topics	Animals Anti-Arrhythmia Agents (therapeutic use, toxicity) Arrhythmias, Cardiac (chemically induced, drug therapy) Calcium Chloride (pharmacology) Drug Evaluation, Preclinical Electrocardiography Female Lethal Dose 50 Male Mice

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