Species and strain differences in mepirizole-induced duodenal and gastric lesions.

Abstract

Species and strain differences in mepirizole-induced duodenal and gastric lesions were studied. Mepirizole at 200 mg/kg given orally induced deep duodenal ulcers and gastric erosions in nonfasted Sprague-Dawley, Fisher, Wistar, and Donryu rats at an incidence of over 75%. Mepirizole at 300 mg/kg given orally also induced penetrating duodenal ulcers in nonfasted rabbits at an incidence of 50%. There was little or no damage to the duodenum and stomach in mice and dogs given 200-300 mg/kg of mepirizole orally or subcutaneously. The stomachs of fasted guinea pigs given 200 mg/kg of mepirizole had superficial erosions at a high incidence (93.3%). Mepirizole at 200 mg/kg given intraduodenally significantly reduced the volume of gastric juice but increased the acidity and pepsin activity in both pylorus-ligated and acute fistula rats. In chronic fistula rabbits, however, the agent at 200 mg/kg given orally reduced the volume and acidity, but increased the pepsin activity. The mechanism of duodenal ulceration by mepirizole differs slightly in rats and rabbits.

• Authors: Y Ishihara, Y Yamada, Y Hata, S Okabe
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 28 Issue 6 Pg. 552-8 (Jun 1983) ISSN: 0163-2116 [Print] United States
• PMID: 6861585 (Publication Type: Journal Article)

Chemical References

• Pyrazoles
• Epirizole

Topics

• Animals
• Dogs
• Duodenal Ulcer (chemically induced)
• Epirizole (toxicity)
• Female
• Gastric Juice (drug effects)
• Guinea Pigs
• Male
• Mice
• Pyrazoles (toxicity)
• Rabbits
• Rats
• Rats, Inbred Strains
• Secretory Rate (drug effects)
• Species Specificity
• Stomach (drug effects)
• Stomach Ulcer (chemically induced)