Abstract |
The effects of oral dipyridamole administration (150 mg) on coronary hemodynamics, myocardial metabolism, and pacing threshold were studied in 10 patients with significant coronary artery disease (CAD). Following dipyridamole through 120 minutes, there was no significant change in resting heart rate, arterial pressure, coronary venous flow, coronary resistance, myocardial lactate extraction, or myocardial oxygen consumption. Rapid atrial pacing performed before and at 60, 90, and 120 minutes after dipyridamole failed to demonstrate any significant reduction in pacing threshold or evidence of increased ischemia after dipyridamole. Blood dipyridamole levels showed variable and slow absorption which probably explains the difference between intravenous and oral dipyridamole on coronary dynamics and myocardial response to pacing.
|
Authors | H S Loeb, J Danoviz, A Miller, R M Gunnar |
Journal | American heart journal
(Am Heart J)
Vol. 105
Issue 6
Pg. 906-10
(Jun 1983)
ISSN: 0002-8703 [Print] United States |
PMID | 6858836
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
|
Topics |
- Administration, Oral
- Aged
- Angina Pectoris
(drug therapy, metabolism, physiopathology)
- Blood Pressure
- Cardiac Pacing, Artificial
- Coronary Circulation
- Dipyridamole
(administration & dosage)
- Heart Rate
- Hemodynamics
- Humans
- Male
- Middle Aged
- Myocardium
(metabolism)
- Oxygen Consumption
- Vascular Resistance
|