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Comparison of amcinonide ointment 0.1 percent twice daily and fluocinonide ointment 0.05 percent three times daily in the treatment of psoriasis.

Abstract
Thirty-nine patients with psoriasis were treated either with amcinonide ointment 0.1 percent twice a day or with fluocinonide ointment 0.05 percent three times a day in a two-week, randomized, parallel-group, double-blind study. The severities of the skin lesions at baseline and at weekly intervals and the overall improvement at weekly intervals were evaluated by the investigator and the patient. The skin lesions improved significantly (p less than or equal to 0.01) over their condition at baseline, with good overall improvement attained by both treatment groups within one week. Both treatments were well tolerated. Amcinonide ointment 0.1 percent applied twice a day was found to be as effective and acceptable to patients as was fluocinonide ointment 0.05 percent applied three times a day in the treatment of psoriasis.
AuthorsR C Cornell
JournalCutis (Cutis) Vol. 31 Issue 5 Pg. 566-9 (May 1983) ISSN: 0011-4162 [Print] United States
PMID6851655 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Ointments
  • Fluocinolone Acetonide
  • Triamcinolone
  • Fluocinonide
  • amcinonide
Topics
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Fluocinolone Acetonide (analogs & derivatives)
  • Fluocinonide (administration & dosage, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Ointments
  • Psoriasis (drug therapy)
  • Triamcinolone (administration & dosage, analogs & derivatives, therapeutic use)

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