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Temperate phage induction and filament formation in Vibrio cholerae by furazolidone.

Abstract
Furazolidone a synthetic nitrofuran used in the treatment of cholera, was found to cause prophage induction and filament formation in Vibrio cholerae. Maximum induction of phage beta was obtained at a drug concentration of 0.5 microgram/ml. Neither induction of prophage nor filamentation took place if the drug treatment was carried out in the presence of 2.5 micrograms/ml chloramphenicol, indicating a requirement for de novo protein synthesis. Our results strongly suggest the existence of "SOS" type functions in Vibrio cholerae.
AuthorsK A Siddiqui, A Ghosh
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 112 Issue 3 Pg. 1106-11 (May 16 1983) ISSN: 0006-291X [Print] United States
PMID6847681 (Publication Type: Journal Article)
Chemical References
  • Furazolidone
  • Chloramphenicol
Topics
  • Chloramphenicol (pharmacology)
  • Furazolidone (pharmacology)
  • Vibrio cholerae (drug effects, ultrastructure)
  • Virus Activation (drug effects)

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