Abstract |
Furazolidone a synthetic nitrofuran used in the treatment of cholera, was found to cause prophage induction and filament formation in Vibrio cholerae. Maximum induction of phage beta was obtained at a drug concentration of 0.5 microgram/ml. Neither induction of prophage nor filamentation took place if the drug treatment was carried out in the presence of 2.5 micrograms/ml chloramphenicol, indicating a requirement for de novo protein synthesis. Our results strongly suggest the existence of "SOS" type functions in Vibrio cholerae.
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Authors | K A Siddiqui, A Ghosh |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 112
Issue 3
Pg. 1106-11
(May 16 1983)
ISSN: 0006-291X [Print] United States |
PMID | 6847681
(Publication Type: Journal Article)
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Chemical References |
- Furazolidone
- Chloramphenicol
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Topics |
- Chloramphenicol
(pharmacology)
- Furazolidone
(pharmacology)
- Vibrio cholerae
(drug effects, ultrastructure)
- Virus Activation
(drug effects)
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